Dangua Fang induces anti-glucolipid metabolism disorder effects similar to those of direct NFIL3 inhibition.

ABSTRACT:

Background

Dangua Fang (DGF) is a traditional Chinese herbal formula widely used to regulate glucolipid metabolism. Nuclear factor, interleukin-3 regulated (NFIL3) plays a regulatory role in intestinal fat absorption and energy metabolism. Gut microbiota can modulate NFIL3 expression and affect host metabolism.

Purpose

This study aimed to investigate the effects of DGF or NFIL3 inhibition on the gut microbiota and their metabolites in mice with glucolipid metabolism disorder (GLMD) and explore the relationship between DGF anti-GLMD effects and those of direct NFIL3 inhibition.

Methods

A GLMD mouse model was established by induction with a high-glucose and high-fat diet. The mice were divided into the control group (CG), model group (MG), DGF group (DFG), DGF + siRNA g

SUBMITTER: Han Z 

PROVIDER: S-EPMC11962013 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature