Spinal hypermobility accelerates ossification in posterior longitudinal ligaments: insights from an <i>in vivo</i> mouse model.

ABSTRACT:

Introduction

Ossification of the posterior longitudinal ligaments (OPLL) is characterized by heterotopic ossification in the posterior longitudinal ligament of spine. Our earlier research found that mechanical stimulation enhances osteogenic differentiation in OPLL-derived ligament cells. Nevertheless, the function of hypermobility of the spine on ligament ossification remain unexplored in vivo.

Methods

We created the novel stimulation device to induce spinal hypermobility in mice with heterotopic ossification of the spine ligaments. The mice were randomly divided into three groups, control, slow hypermobility (SH) group and fast hypermobility (FH) group according to the frequency of spinal movement. Ligament ossification and changes in spinal range of motion (ROM) we

SUBMITTER: Tang T 

PROVIDER: S-EPMC11962021 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature