Increased Brain Age Among Psychiatrically Healthy Adults Exposed to Childhood Trauma.

ABSTRACT:

Background

Adults with childhood trauma exposure may exhibit brain changes typically associated with aging and neurodegeneration (e.g., reduced tissue volume or integrity) to a greater degree than their unexposed counterparts, suggesting accelerated brain aging. Machine learning methods that predict a person's age based on their magnetic resonance imaging (MRI) brain scan may be useful for investigating aberrant brain aging following childhood trauma exposure. Emerging evidence indicates altered brain aging in adolescents with childhood trauma exposure; however, this association has not been examined in healthy adults.

Methods

We investigated the associations between childhood trauma exposure, including abuse and neglect, and brain-predicted age in psychiatrically healthy ad

SUBMITTER: Hendrikse C 

PROVIDER: S-EPMC11962057 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature