Association between mild renal insufficiency, inflammatory status on initial admission, and 1-year mortality following ST-segment elevation myocardial infarction.

ABSTRACT: The systemic inflammation tends to increase progressively as kidney function deteriorates. However, it remains unknown whether mild renal insufficiency affects inflammatory response at admission and subsequent clinical outcomes following ST-segment elevation myocardial infarction (STEMI). This study aimed to evaluate the joint, interactive, and mediating effects of estimated glomerular filtration rate (eGFR) and neutrophil-lymphocyte ratio (NLR) at admission on 1-year mortality in STEMI patients. Data were collected from 5,594 consecutive STEMI patients at seven centers (NCT04996901). Mildly reduced eGFR (60-89 mL/min/1.73m²) was associated with both elevated NLR and increased 1-year mortality (β 0.55, 95%CI [0.07-1.02], P = 0.024; HR 2.18, 95%CI [1.55-3.08], P < 0.001; respecti

SUBMITTER: Luo D 

PROVIDER: S-EPMC11962060 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature