Apolipoprotein D is crucial for promoting perineural invasion in salivary adenoid cystic carcinoma.

ABSTRACT:

Background

Perineural invasion (PNI) is a prevalent phenomenon in salivary adenoid cystic carcinoma (SACC). Nevertheless, the regulatory mechanism of PNI is largely elusive.

Methods

We detected Apolipoprotein D (ApoD) expression and further determined its role in SACC progression. Subsequently, the contributions of SACC-derived ApoD on neurite outgrowth of dorsal root ganglions (DRGs) cells were explored. Moreover, a series of in vivo assays were conducted to elucidate the role of ApoD in the SACC PNI process.

Results

We observed a dramatic up-regulation of ApoD in the SACC associated with an enhancement of PNI in patient biopsies. We found that SACC-derived ApoD elevated cancer cell migration and invasion. In addition, ApoD could facilitate the neurite outgrowth of c

SUBMITTER: Huang G 

PROVIDER: S-EPMC11962118 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature