Mutational profiling using liquid biopsy to guide targeted therapy in patients with metastatic cancer.

ABSTRACT: Liquid biopsy gained significant interest in the area of cancer management. This study aims to evaluate the effectiveness of molecular testing using ctDNA (circulating tumor DNA) to; detect genetic alterations, screen for abnormalities, identify mutations associated with treatment sensitivity or resistance and guide therapy decision for several types of cancer in patients with metastasis. A total of 85 samples were collected from 74 patients recruited at our center, as part of their routine clinical follow-up. 17 different cancer types were analyzed. Genetic testing was conducted in patients with metastasis after failure of standard treatments. Sequencing was conducted in plasma-ctDNA samples; and when it was possible on the tumor tissue as well. Our analysis revealed that 88% (65 patients

SUBMITTER: Mazouji O 

PROVIDER: S-EPMC11962155 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature