IS26-associated In4-type integrons forming multiresistance loci in enterobacterial plasmids.

ABSTRACT: Three distinct multiresistant loci from enterobacterial plasmids each comprised an integron and an IS26-associated sequence. Sequence comparison suggested a common ancestral structure that derived from an IS26 insertion into the 5' conserved segment of an In4-type integron and evolved through acquisition of gene cassettes and IS26-mediated recruitment of additional resistance genes of diverse origin.

SUBMITTER: Miriagou V 

PROVIDER: S-EPMC1196216 | biostudies-literature | 2005 Aug

REPOSITORIES: biostudies-literature