Two-year impact of COVID-19: Longitudinal MRI brain changes and neuropsychiatric trajectories.

ABSTRACT:

Aim

Up to 10% of SARS-CoV-2 infected individuals suffer from post-COVID-19 condition, marked by fatigue and cognitive dysfunction as major symptoms. Longitudinal studies on neuropsychological and clinical trajectories and related brain changes are scarce. Here, we aimed to examine their evolution up to 2 years post-infection.

Methods

In a multi-center, longitudinal study of 79 post-COVID patients (mean age 46, 48 female) with persistent symptoms and 21 age- and sex-matched never-infected, healthy controls (mean age 42, eight female), we analyzed neuropsychological performance, self-reported outcomes and associated neuroimaging alterations of resting-state functional and structural magnetic resonance imaging data 23 months post-infection.

Results

In post-COVID patients

SUBMITTER: Dadsena R 

PROVIDER: S-EPMC11962352 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature