RpoB mutations and their association with rifampicin resistance in clinical Staphylococcus epidermidis.

ABSTRACT:

Background

Staphylococcus epidermidis is a ubiquitous member of the healthy skin and mucous microbiota but is also an opportunistic pathogen responsible for various infections, often treated with antibiotics like rifampicin. Resistance to rifampicin in S. epidermidis arises primarily through nonsynonymous mutations in the rpoB gene.

Objectives

To investigate the prevalence of rpoB mutations and their association with phenotypic rifampicin resistance in clinical S. epidermidis isolates from Denmark, France, and Sweden.

Methods

All clinical isolates (N = 942) were whole-genome sequenced to identify mutations in rpoB and subsequently linked to phenotypic rifampicin resistance based on antimicrobial susceptibility testing.

Results

A total of 64 (6.8%) isolates were

SUBMITTER: Edslev SM 

PROVIDER: S-EPMC11962384 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature