High Glucose Contribution to the TCA Cycle Is a Feature of Aggressive Non-Small Cell Lung Cancer in Patients.

ABSTRACT:

Significance

Intraoperative 13C-glucose infusions in patients with NSCLC show that tumors with high labeling of TCA cycle intermediates progress rapidly, resulting in metastasis and early death. Blocking this pathway suppresses metastasis of human NSCLC cells in mice.

SUBMITTER: Cai L 

PROVIDER: S-EPMC11962397 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature