Microtubules Disruption Alters the Cellular Structures and Mechanics Depending on Underlying Chemical Cues.

ABSTRACT: The extracellular matrix determines cell morphology and stiffness by manipulating the cytoskeleton. The impacts of extracellular matrix cues, including the mechanical and topographical cues on microtubules and their role in biological behaviors, are previously studied. However, there is a lack of understanding about how microtubules (MTs) are affected by environmental chemical cues, such as extracellular matrix density. Specifically, it is crucial to understand the connection between cellular morphology and mechanics induced by chemical cues and the role of microtubules in these cellular responses. To address this, surfaces with high and low cRGD (cyclic Arginine-Glycine-Aspartic acid) peptide ligand densities are used. The cRGD is diluted with a bioinert ligand to prevent surface native c

SUBMITTER: Abdellatef SA 

PROVIDER: S-EPMC11962689 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature