ATP-Regulated Formation of Transient Peptide Amphiphiles Superstructures.

ABSTRACT: Self-assembly of biotic systems serves as inspiration for the preparation of synthetic supramolecular assemblies to mimic the structural, temporal, and functional aspects of living systems. Despite peptide amphiphiles (PAs) being widely studied in the context of biomimetic and bioactive functional nanomaterials, very little is currently known about the reversible and spatiotemporal control of their hierarchical self-assemblies. Here, it is shown that PA-based supramolecular nanofibers can transiently form superstructures, through binding with oppositely charged adenosine triphosphate (ATP), leading to charge screening and stabilization of bundled nanofibers. Enzymatic hydrolysis of ATP to adenosine monophosphate and phosphates causes the disassembly of the superstructures and recovery of i

SUBMITTER: Cappelletti D 

PROVIDER: S-EPMC11962707 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature