D-amino acid enhanced the sensitivity of avian pathogenic <i>Escherichia coli</i> to tetracycline and amikacin.

ABSTRACT: Avian pathogenic Escherichia coli (APEC) biofilm formation has led to increased antibiotic resistance, presenting a significant challenge for the prevention and control of the disease. While certain D-amino acids (D-AAs) have been shown to inhibit the formation of various bacterial biofilms, role in APEC biofilms remains unexplored. This study investigates the effects of 19 different D-AAs on clinically isolated APEC biofilm. The results showed that D-tyrosine (D-Tyr), D-leucine (D-Leu), D-tryptophan (D-Trp), and D-methionine (D-Met) can reduce APEC formation by over 50% at a concentration of 5 mM. Subsequently, four D-AAs were selected for combination treatment with antibiotics (ceftazidime, amikacin, tetracycline, and ciprofloxacin). The findings reveal that D-Tyr enhance the sens

SUBMITTER: Wu J 

PROVIDER: S-EPMC11962725 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature