Plasma levels of polyols erythritol, mannitol, and sorbitol and incident coronary heart disease among women.

ABSTRACT:

Aims

Erythritol, a sugar alcohol (polyol), has recently been linked to the risk of major adverse cardiovascular events. We investigated whether plasma erythritol and other polyols (mannitol/sorbitol) were associated with the risk of incident coronary heart disease (CHD).

Methods and results

This prospective nested case-control study included 762 incident cases of CHD and 762 controls from the Nurses' Health Study. Plasma concentrations of polyols were measured at baseline (1989-90 or 2000-02). Associations of erythritol with cardiometabolic risk factors were also analysed in the Women's Lifestyle Validation Study (n = 728; blood collected in 2010-12). Higher erythritol levels were related to more adverse cardiometabolic risk factor status. A relative risk (RR) for CHD per 1-

SUBMITTER: Heianza Y 

PROVIDER: S-EPMC11962730 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature