Phase Locking of 40 Hz Auditory Steady State Responses Is Modulated by Sensory Predictability and Linked to Cerebellar Myelination.

ABSTRACT: 40 Hz auditory steady-state responses (ASSR) can be evoked by brief auditory clicks delivered at 40 Hz. While the neuropharmacology behind the generation of ASSR is well examined, the link between ASSR and microstructural properties of the brain is unclear. Further, whether the 40 Hz ASSR can be manipulated through processes involving top-down control, such as prediction, is currently unknown. We recorded EEG in 50 neurotypical participants while they engaged in a 40 Hz auditory steady-state paradigm. We manipulated the predictability of the stimuli to test the modulatory effect of prediction on 40 Hz steady-state responses. Further, we acquired T1w and T2w structural MRI on the same individuals and used the T1/T2 ratio as a proxy to determine myelination content in gray matter. The phase

SUBMITTER: Larsen KM 

PROVIDER: S-EPMC11962760 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature