Anti-pentraxin 3 antibodies and residual disease activity in rheumatoid arthritis.

ABSTRACT:

Objectives

This study quantified anti-PTX3 antibodies in the serum of seropositive and seronegative RA patients, examining their associations with disease activity and patient-reported outcome measures (PROMs).

Methods

In this cross-sectional study, RA patients diagnosed per ACR/EULAR 2010 criteria were recruited. Seronegative RA was defined as ACPA <7 kU/L. Data on demographics, clinical characteristics, medications, and PROMs were collected. Serum anti-PTX3 antibodies were measured using an in-house ELISA method. Comparative analyses were conducted with historical controls having PsA and FM.

Results

The cohort included 83 RA patients (42 seropositive, 41 seronegative). Seropositive patients had lower anti-PTX3 antibody levels than PsA (P = 0.001) and FM (P = 0.004)

SUBMITTER: Salvato M 

PROVIDER: S-EPMC11962886 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature