Evaluating CA-125 and PET/CT for cancer detection in idiopathic inflammatory myopathies.

ABSTRACT:

Objective

This study aims to evaluate the diagnostic accuracy of CA-125 and PET/CT in detecting cancer among adult patients with idiopathic inflammatory myopathy (IIM).

Methods

We conducted a retrospective study of a single-centre cohort of adult IIM patients enrolled from 2003 to 2020. Data on CA-125 and PET/CT tests conducted within five years of IIM symptom onset were extracted from electronic medical records. The outcomes assessed included true-positive, false-positive, true-negative and false-negative results.

Results

Among 1432 patients with IIM, 250 CA-125 tests were conducted on 205 patients within the first five years of symptom onset, yielding a false-positive rate of 3.1% and a false-negative rate of 14.3%. Most false-positives were associated with endometr

SUBMITTER: Wang X 

PROVIDER: S-EPMC11962979 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature