Sex-specific associations between cerebrospinal fluid inflammatory biomarkers and cognition in antiretroviral-naive people with HIV in rural Uganda.

ABSTRACT: Globally, people with HIV (PWH) experience a broad spectrum of cognitive impairment that can be noted both before and after initiation of antiretroviral therapy (ART). Sex differences in immune function have been implicated in differential cognitive outcomes. Here, we report sex differences in cerebrospinal fluid (CSF) markers in relation to cognitive performance in a subset of ART-naïve PWH participating in the Rakai Neurology Cohort Study. Participants (55 % male, 45 % female, overall mean age 36.5 years, SD = 8.7) underwent a lumbar puncture and a cognitive battery prior to ART initiation. CSF was collected, and 14 inflammatory markers were analyzed. Individual cognitive test z-scores were generated based on local normative data. We used a series of least absolute shrinkage and selectio

SUBMITTER: Denniss J 

PROVIDER: S-EPMC11962998 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature