Changes in infant porcine pulmonary tissue oxylipins induced by cardiopulmonary bypass.

ABSTRACT:

Background

Oxylipins are metabolites derived from fatty acids such as arachidonic acid (AA) and are key mediators in inflammation, host defense, and tissue injury. Serum oxylipins increase in adults after cardiopulmonary bypass (CPB) but tissue-level changes are poorly defined. The objective of this study was to characterize pulmonary tissue oxylipins in an infant porcine model of CPB with deep hypothermic circulatory arrest (DHCA).

Methods

Infant pigs underwent CPB with DHCA. Controls received anesthesia only. Right upper and lower lobes of the lung underwent oxylipin analysis via liquid chromatography-tandem mass spectrometry. One-way ANOVA was utilized to assess differences in oxylipin concentrations across groups, followed by pairwise comparisons.

Results

AA and m

SUBMITTER: Iguidbashian KG 

PROVIDER: S-EPMC11962999 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature