N-Lactoyl amino acids as metabolic biomarkers differentiating low and high exercise response.

ABSTRACT: Aerobic physical exercise has significant benefits for cardiovascular health; however, some individuals experience no benefit or even adverse effects. One reason for poor tolerance to aerobic exercise may be a low percentage of slow-twitch (oxidative) muscle fibers. This study aims to identify the metabolic signatures associated with low and high response to exercise by comparing the metabolic profiles of participants categorized according to their improvement of the 6-minute walking distance. In this study, pre- and postexercise intervention measurements of the 6-minute walking distance were conducted in forty-three lean and overweight young women, followed by non-targeted metabolomics analysis of 1039 known metabolites. An independent validation cohort comprising 791 individuals from the

SUBMITTER: Sellami M 

PROVIDER: S-EPMC11963115 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature