Comparative efficacy and safety of local anesthesia combinations for labor pain relief: a network meta-analysis.

ABSTRACT:

Background

Epidural anesthesia stands out as the most commonly employed approach for labor analgesia, frequently complemented by various local anesthetics, and the analgesic effectiveness and safety profiles of distinct local anesthetic regimens are different. To compare the efficacy and adverse reactions of different local anesthetic regimens in relieving labor pain by performing a network meta-analysis.

Methods

We systematically searched four electronic databases (PubMed, EMBASE, Web of Science, and Cochrane Library) for randomized controlled trials from the inception of the databases up to March 3, 2025. Included in the study were patients aged 18 to 35 years who underwent painless delivery under epidural anesthesia.

Results

The meta-analysis included a total of 59

SUBMITTER: Li P 

PROVIDER: S-EPMC11963270 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature