School-age outcomes among IVF and ICSI-conceived children: a causal inference analysis using linked population-wide data.

ABSTRACT:

Background

Use of intracytoplasmic sperm injection (ICSI) continues to increase as the most common mode of oocyte insemination during in vitro fertilisation (IVF), sometimes in the absence of clear indications (i.e. male factor infertility). Several studies suggest an increased risk of congenital abnormalities after ICSI. The association between the ICSI technique and long-term childhood development remains unclear.

Methods

Our population-based study included singleton infants conceived via IVF and born between 2005 and 2013. The cohort included state-wide linked maternal and childhood administrative data from Victoria, Australia. The primary exposure was conception via ICSI (without severe male factor infertility), with those born following standard IVF as controls. Childho

SUBMITTER: Kennedy AL 

PROVIDER: S-EPMC11963277 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature