DCE-MRI radiomics of primary breast lesions combined with ipsilateral axillary lymph nodes for predicting efficacy of NAT.

ABSTRACT:

Background

This study aimed to assess the predictive value of radiomic analysis derived from primary lesions and ipsilateral axillary suspicious lymph nodes (SLN) on dynamic contrast-enhanced MRI (DCE-MRI) for evaluating the response to neoadjuvant therapy (NAT) in early high-risk and advanced breast cancer (BC) patients.

Methods

A retrospective analysis was conducted on 222 BC patients (192 from Center I and 30 from Center II) who underwent NAT. Radiomic features were extracted from the primary lesion (intra- and peritumoral regions) and ipsilateral axillary SLN to develop radiomic signatures (RS-primary, RS-SLN). An integrated signature (RS-Com) combined features from both regions. Feature selection was performed using correlation analysis, the Mann-Whitney U test, and lea

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11963401 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature