Sex differences in systematic screening for tuberculosis among antiretroviral therapy naive people with HIV in Kampala, Uganda.

ABSTRACT:

Background

Systematic tuberculosis (TB) screening is recommended for all people with HIV (PWH) because of its potential to improve TB outcomes through earlier diagnosis and treatment initiation. As such, systematic screening may be particularly important for men, who experience excess TB prevalence and mortality compared to women. We assessed sex differences among PWH undergoing systematic TB screening, including TB prevalence and severity, diagnostic accuracy of screening tools, and TB outcomes.

Methods

We enrolled and followed adults with HIV (CD4 ≤ 350 cells/µL) initiating antiretroviral therapy (ART) at two HIV/AIDS clinics in Uganda from July 2013 to December 2016. All participants underwent TB screening and sputum collection for TB testing (Xpert MTB/RIF [Xpert], cultu

SUBMITTER: Chaisson LH 

PROVIDER: S-EPMC11963461 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature