Epidemiological and genetic characterizations of hand, foot, and mouth disease and acute respiratory infections due to CV-A6 infection in Henan Province, China between 2021 and 2022.

ABSTRACT: Coxsackievirus (CV) A6 has been widely considered as the main cause of global hand, foot, and mouth disease (HFMD) outbreaks. Despite the serious threat to children's health posed by the emerging CV-A6, our knowledge of the epidemiological features and etiology of HFMD caused by the new CV-A6 strains remains limited. In the present study, we aimed to investigate the epidemiological and genetic characterizations of CV-A6-associated HFMD outbreaks in Henan Province, China between 2021 and 2022. Clinical data and biospecimens of 407 children with mild and severe CV-A6 infection from Henan Children's Hospital (Children's Hospital Affiliated to Zhengzhou University) were collected for this prevalence study. Logistic regression analysis was employed to assess potential risk factors for severe il

SUBMITTER: Li X 

PROVIDER: S-EPMC11963518 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature