Pharmacokinetics of islatravir in participants with moderate hepatic impairment.

ABSTRACT: Islatravir (ISL) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment of HIV-1 infection. People living with HIV are at risk of liver disease. ISL is metabolized by adenosine deaminase (ADA), which is expressed in the liver; thus, ISL pharmacokinetics (PK) may be affected by hepatic impairment. This study evaluated the effect of moderate hepatic impairment on ISL PK. This nonrandomized, open-label, phase 1 study (MK-8591-030) evaluated the effects of a single oral dose of ISL 60 mg in HIV-seronegative adults with moderate hepatic insufficiency (n = 6) and matched healthy adult participants (n = 6). Blood samples for plasma ISL and 4'-ethynyl-2-fluoro-2'deoxyinosine (M4) and peripheral blood mononuclear cell (PBMC) ISL-triphosphate (IS

SUBMITTER: Matthews RP 

PROVIDER: S-EPMC11963540 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature