Genome-wide DNA methylation patterns in Daphnia magna are not significantly associated with age.

ABSTRACT:

Background

DNA methylation plays a crucial role in gene regulation and epigenetic inheritance across diverse organisms. Daphnia magna, a model organism in ecological and evolutionary research, has been widely used to study environmental responses, pharmaceutical toxicity, and developmental plasticity. However, its DNA methylation landscape and age-related epigenetic changes remain incompletely understood.

Results

In this study, we characterized DNA methyltransferases (DNMTs) and mapped DNA methylation across the D. magna genome using whole-genome bisulfite sequencing. Our analysis identified three DNMTs: a highly expressed but nonfunctional de novo methyltransferase (DNMT3.1), alongside lowly expressed yet functional de novo methyltransferase (DNMT3.2) and maintenance methyl

SUBMITTER: Liu R 

PROVIDER: S-EPMC11963560 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature