O8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.

ABSTRACT:

Background

Lung cancer is a serious threat to human life and health, but effective screening and treatment methods are lacking. Circular RNAs (circRNAs) have important biological functions and are closely related to tumour development. Some studies have shown that the 8-oxo-7,8-dihydroguanosine (o8G) modification plays a key role in the disease process, but the effect of the o8G modification on circRNAs has not been elucidated. Moreover, cuproptosis is a novel mode of cell death in which copper ions directly promote protein aggregation and the disruption of cellular metabolic pathways. The present study revealed that the o8G modification of circKIAA1797 occurs and promotes lung cancer development by inhibiting cuproptosis, which provides new perspectives for epitranscriptomic studi

SUBMITTER: Xu H 

PROVIDER: S-EPMC11963662 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature