Do the monocyte-derived dendritic cells exert a pivotal role in the early onset of experimental autoimmune uveitis?

ABSTRACT:

Background

Eyes are recognized as immunological privileged site. However, the onset of autoimmune uveitis (AU) prompts an influx of dendritic cells (DCs) into the retinas, tasked with presenting auto-antigens, thereby exacerbating the inflammatory response. Monocyte-derived DCs (moDCs) implicated in various autoimmune disorders, but their specific involvement in AU remains unclear. This study aims to investigate the constitution and dynamics of retinal DCs subsequent to the induction of experimental autoimmune uveitis (EAU).

Methods

In our study, an EAU model was established in C57BL/6J mice, and prednisolone acetate (PA) eye drops were administrated unilaterally to the right eye from 5 days post-immunization (dpi). The infiltration of Gr-1⁺CD115⁺CD11c<

SUBMITTER: Yuan B 

PROVIDER: S-EPMC11963667 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature