CSF outflow from the human spinal canal: preliminary results from an anatomical specimen-based model.

ABSTRACT:

Background

Recent discoveries focused on the role of cerebrospinal fluid (CSF) in metabolite clearance have initiated intense research on CSF circulation and outflow pathways. These studies have focused on the cranial subarachnoid space, whereas spinal outflow has been relatively less investigated. Moreover, most studies have been performed on rodent models, which allows thorough anatomical investigation, whereas evidence from humans has been generated primarily from in vivo neuroimaging techniques. In this paper, we introduce an anatomical specimen-based preparation for studying spinal CSF outflow in humans and present preliminary results from our initial studies.

Methods

Unfixed anatomical specimens of the thoracolumbar spinal dural sac along with the spinal nerves were ob

SUBMITTER: Rzeplinski R 

PROVIDER: S-EPMC11963703 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature