A new susceptibility locus for migraine with aura in the 15q11-q13 genomic region containing three GABA-A receptor genes.

ABSTRACT: Migraine is the most common type of chronic episodic headache. Several population-based family studies have suggested a strong genetic predisposition to migraine, especially migraine with aura (MA). Although several susceptibility loci have been identified, none of the numerous studies performed to date have led to the identification of a gene responsible for the more common forms of migraine. GABA-A receptors and their modulator sites seem to be involved in the pathophysiological events that underlie migraine. We report on clinical and molecular data from a total of 10 families with MA, in which MA segregates as an autosomal dominant trait and presents with homogeneous clinical features. After excluding linkage with the known candidate loci, we used a functional candidate approach and gen

SUBMITTER: Russo L 

PROVIDER: S-EPMC1196377 | biostudies-literature | 2005 Feb

REPOSITORIES: biostudies-literature