Identification of proteins associated with type 2 diabetes risk in diverse racial and ethnic populations.

ABSTRACT:

Aims/hypothesis

Several studies have reported associations between specific proteins and type 2 diabetes risk in European populations. To better understand the role played by proteins in type 2 diabetes aetiology across diverse populations, we conducted a large proteome-wide association study using genetic instruments across four racial and ethnic groups: African; Asian; Hispanic/Latino; and European.

Methods

Genome and plasma proteome data from the Multi-Ethnic Study of Atherosclerosis (MESA) study involving 182 African, 69 Asian, 284 Hispanic/Latino and 409 European individuals residing in the USA were used to establish protein prediction models by using potentially associated cis- and trans-SNPs. The models were applied to genome-wide association study summary statistics

SUBMITTER: Liu S 

PROVIDER: S-EPMC11963907 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature