Population structure, admixture, and aging-related phenotypes in African American adults: the Cardiovascular Health Study.

ABSTRACT: U.S. populations are genetically admixed, but surprisingly little empirical data exists documenting the impact of such heterogeneity on type I and type II error in genetic-association studies of unrelated individuals. By applying several complementary analytical techniques, we characterize genetic background heterogeneity among 810 self-identified African American subjects sampled as part of a multisite cohort study of cardiovascular disease in older adults. On the basis of the typing of 24 ancestry-informative biallelic single-nucleotide-polymorphism markers, there was evidence of substantial population substructure and admixture. We used an allele-sharing-based clustering algorithm to infer evidence for four genetically distinct subpopulations. Using multivariable regression models, we d

SUBMITTER: Reiner AP 

PROVIDER: S-EPMC1196398 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature