Inositol 1,4,5-Trisphosphate Receptors Regulate Vascular Smooth Muscle Cell Proliferation and Neointima Formation in Mice.

ABSTRACT:

Background

Vascular smooth muscle cell (VSMC) proliferation is involved in many types of arterial diseases, including neointima hyperplasia, in which Ca²⁺ has been recognized as a key player. However, the physiological role of Ca²⁺ release via inositol 1,4,5-trisphosphate receptors (IP₃Rs) from endoplasmic reticulum in regulating VSMC proliferation has not been well determined.

Methods and results

Both in vitro cell culture models and in vivo mouse models were generated to investigate the role of IP₃Rs in regulating VSMC proliferation. Expression of all 3 IP₃R subtypes was increased in cultured VSMCs upon platelet-derived growth factor-BB and FBS stimulation as well as in the left carotid artery undergoing intimal thicke

SUBMITTER: Huang F 

PROVIDER: S-EPMC11964046 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature