Obstructive Sleep Apnea, Platelet Aggregation, and Cardiovascular Risk.

ABSTRACT:

Background

Although related, the precise mechanisms linking obstructive sleep apnea (OSA) and cardiovascular disease (CVD) are unclear. Platelets are mediators of CVD risk and thrombosis and prior studies suggested associations of OSA and platelet activity. The aim of this study is to assess the link between OSA, platelet activity, and CVD-related risk factors.

Methods and results

We studied the association of OSA-measures and platelet aggregation in participants dually enrolled in the SHHS (Sleep Heart and Health Study) and FHS (Framingham Heart Study). We applied linear regression models with adjustment for demographic and clinical covariates and explored interactions with OSA and CVD-related factors, including age, sex, body mass index, hypertension, OSA diagnosis (apnea-

SUBMITTER: Kovbasyuk Z 

PROVIDER: S-EPMC11964063 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature