Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population.

ABSTRACT: Cardiovascular diseases, including myocardial infarction (MI) and stroke, most often occur on the background of atherosclerosis, a condition attributed to the interactions between multiple genetic and environmental risk factors. We recently reported a linkage and association study of MI and stroke that yielded a genetic variant, HapA, in the gene encoding 5-lipoxygenase-activating protein (ALOX5AP), that associates with both diseases in Iceland. We also described another ALOX5AP variant, HapB, that associates with MI in England. To further assess the contribution of the ALOX5AP variants to cardiovascular diseases in a population outside Iceland, we genotyped seven single-nucleotide polymorphisms that define both HapA and HapB from 450 patients with ischemic stroke and 710 controls from Abe

SUBMITTER: Helgadottir A 

PROVIDER: S-EPMC1196409 | biostudies-literature | 2005 Mar

REPOSITORIES: biostudies-literature