Hawkmoth Pheromone Transduction Involves G-Protein-Dependent Phospholipase Cβ Signaling.

ABSTRACT: Evolutionary pressures adapted insect chemosensation to their respective physiological needs and tasks in their ecological niches. Solitary nocturnal moths rely on their acute olfactory sense to find mates at night. Pheromones are detected with maximized sensitivity and high temporal resolution through mechanisms that are mostly unknown. While the inverse topology of insect olfactory receptors and heteromerization with the olfactory receptor coreceptor suggest ionotropic transduction via odorant-gated receptor-ion channel complexes, contradictory data propose amplifying G-protein-coupled transduction. Here, we used in vivo tip-recordings of pheromone-sensitive sensilla of male Manduca sexta hawkmoths at specific times of day (rest vs activity). Since the olfactory receptor neurons d

SUBMITTER: Schneider AC 

PROVIDER: S-EPMC11964160 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature