ABO blood group and COVID-19 severity: Associations with endothelial and adipocyte activation in critically ill patients.

ABSTRACT:

Background

ABO blood group has been implicated both in susceptibility to, and severity of, SARS-CoV-2 infection. The aim of this study was to explore a potential association between ABO blood group and severity of COVID-19 infection in critically ill patients and the following biological mechanisms: inflammatory cytokines, endothelial injury, and adipokines.

Methods

We conducted a retrospective study of 128 critically ill COVID-19 patients admitted to Vancouver General Hospital from March 2020-March 2021. Outcomes including 28-day mortality, need for mechanical ventilation and length of intensive care unit (ICU) stay were compared between patients with A & AB blood type vs. B & O blood type. Likewise, serum inflammatory markers, markers of endothelial activation, and adipoki

SUBMITTER: Stukas S 

PROVIDER: S-EPMC11964209 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature