T-cell activation and senescence in asymptomatic HIV/Leishmania infantum co-infection.

ABSTRACT:

Background

Leishmania infantum can be an opportunistic pathogen, with an immunocompromised status increasing the risk of converting asymptomatic infection to symptomatic visceral leishmaniasis (VL). VL has approximately 5% fatality rate; and HIV coinfection (AIDS/VL) increases this risk. We hypothesized that, relative to those with HIV alone, people with co-infection would have altered T cell activation which could impact on the risk of VL.

Methods

A cross-sectional study was performed between 2014 and 2016 to determine the prevalence of L. infantum infection in people living with HIV (PLHIV) residing in Brazil (n = 1,372). Subsequent incident cases of VL were ascertained from a public health database through 2018 and from a cohort of families with VL. Immune status of 69 pa

SUBMITTER: de Oliveira Mendes-Aguiar C 

PROVIDER: S-EPMC11964262 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature