Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice.

ABSTRACT: Targeting adverse pathogenic gut microbiota regulation through fecal microbiota transplantation (FMT) may restore health and has been validated in some aging-related diseases. However, the mechanisms of the gut microbiota's role in frailty and whether modulation of the gut microbiota can treat age-related frailty remain largely unknown. To assess the effects of FMT on frailty, we used bidirectional fecal microbiota transplantation in young and old mice. We demonstrated that fecal bacteria transplanted from old mice into young mice reduced body weight and grip strength (p=0.002), and led to elevated inflammatory factors in young mice, but had no significant effect on intestinal barrier function. Notably, FMT treatment in older mice not only improved frailty (grip strength: p=0.036, low phys

SUBMITTER: Zhu M 

PROVIDER: S-EPMC11964440 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature