Archaic introgression and the distribution of shared variation under stabilizing selection.

ABSTRACT: Many phenotypic traits are under stabilizing selection, which maintains a population's mean phenotypic value near some optimum. The dynamics of traits and trait architectures under stabilizing selection have been extensively studied for single populations at steady state. However, natural populations are seldom at steady state and are often structured in some way. Admixture and introgression events may be common, including over human evolutionary history. Because stabilizing selection results in selection against the minor allele at a trait-affecting locus, alleles from the minor parental ancestry will be selected against after admixture. We show that the site-frequency spectrum can be used to model the genetic architecture of such traits, allowing for the study of trait architecture dynam

SUBMITTER: Ragsdale AP 

PROVIDER: S-EPMC11964463 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature