Head-to-head comparison of ¹⁸F-sodium fluoride coronary PET imaging between a silicon photomultiplier with digital photon counting and conventional scanners.

ABSTRACT:

Background

We compared silicone photomultipliers with digital photon counting (SiPM) and photomultiplier tubes (PMT) positron emission tomography (PET) in imaging coronary plaque activity with ¹⁸F-sodium fluoride (¹⁸F-NaF) and evaluated comprehensively SiPM PET reconstruction settings.

Methods

In 25 cardiovascular disease patients (mean age 67 ± 12 years), we conducted ¹⁸F-NaF PET on a SiPM (Biograph Vision) and conventional PET (Discovery 710) on the same day as part of a prospective clinical trial (NCT03689946). Following administration of 250 MBq of ¹⁸F-NaF, patients underwent a contrast-enhanced CT angiography and a 30-min PET acquisition in list-mode on each PET consecutively. Image noise was defined as mean standard deviation

SUBMITTER: Hashimoto H 

PROVIDER: S-EPMC11964467 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature