Microbiota contribute to regulation of the gut-testis axis in seasonal spermatogenesis.

ABSTRACT: Seasonal breeding is an important adaptive strategy for animals. Recent studies have highlighted the potential role of the gut microbiota in reproductive health. However, the relationship between the gut microbiota and reproduction in seasonal breeders remains unclear. In this study, we selected a unique single food source animal, the flying squirrel (Trogopterus xanthipes), as a model organism for studying seasonal breeding. By integrating transcriptomic, metabolomic, and microbiome data, we comprehensively investigated the regulation of the gut-metabolism-testis axis in seasonal breeding. Here, we demonstrated a significant spermatogenic phenotype and highly active spermatogenic transcriptional characteristics in the testes of flying squirrels during the breeding season, which were assoc

SUBMITTER: Wu Z 

PROVIDER: S-EPMC11964897 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature