Macrophages protect against sensory axon loss in peripheral neuropathy.

ABSTRACT: Peripheral neuropathy is a common complication of type 2 diabetes, which is strongly associated with obesity¹, causing sensory loss and, in some patients, neuropathic pain^2,3. Although the onset and progression of diabetic peripheral neuropathy is linked with dyslipidaemia and hyperglycaemia⁴, the contribution of inflammation to peripheral neuropathy pathogenesis has not been investigated. Here we used a high-fat, high-fructose diet (HFHFD), which induces obesity and prediabetic metabolic changes, to study the onset of peripheral neuropathy. Mice fed the HFHFD developed persistent heat hypoalgesia after 3 months, but a reduction in epidermal skin nerve fibre density manifested only at 6 months. Using single-cell sequencing, we found that CCR2⁺ ma

SUBMITTER: Hakim S 

PROVIDER: S-EPMC11964918 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature