Metabolic modelling reveals the aging-associated decline of host-microbiome metabolic interactions in mice.

ABSTRACT: Aging is accompanied by considerable changes in the gut microbiome, yet the molecular mechanisms driving aging and the role of the microbiome remain unclear. Here we combined metagenomics, transcriptomics and metabolomics from aging mice with metabolic modelling to characterize host-microbiome interactions during aging. Reconstructing integrated metabolic models of host and 181 mouse gut microorganisms, we show a complex dependency of host metabolism on known and previously undescribed microbial interactions. We observed a pronounced reduction in metabolic activity within the aging microbiome accompanied by reduced beneficial interactions between bacterial species. These changes coincided with increased systemic inflammation and the downregulation of essential host pathways, particularly i

SUBMITTER: Best L 

PROVIDER: S-EPMC11964932 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature