Niraparib as maintenance therapy in Japan: a retrospective observational study using a Japanese claims database.

ABSTRACT:

Objective

Epithelial ovarian cancer (EOC) is the leading cause of female mortality in gynecologic malignancies, with a rising incidence in Japan. This study aimed to validate the treatment patterns and safety of niraparib as maintenance therapy for EOC following initial chemotherapy in clinical practice in Japan.

Methods

Leveraging claims data between April 2008 and December 2022, this descriptive study comprised EOC-diagnosed patients receiving initial platinum-based chemotherapy, debulking surgery, and niraparib as maintenance therapy. Patient characteristics, prescription status, transfusion details, and laboratory data were assessed and reported as summary statistics and frequencies.

Results

Among 291 patients, the median age was 64.0 years and 94.5% received a 20

SUBMITTER: Motohashi T 

PROVIDER: S-EPMC11964971 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature