Heterogeneity of reduced FEV₁ in early adulthood: A looking forward, looking backwards analysis.

ABSTRACT:

Background

Some individuals never achieve normal peak FEV₁ in early adulthood. It is unknown if this is due to airflow limitation and/or lung restriction.

Methods

To investigate this, we: (1) looked forward in 19,791 participants in the Dutch Lifelines general population cohort aged 25-35 years with 5-year follow-up; and (2) looked backwards in 2032 participants in the Swedish BAMSE birth cohort with spirometry at 24 years of age but also at 16 and/or 8 years.

Results

(1) In Lifelines 8.5% of participants had reduced FEV₁ at 25-35 years, 68% due to Preserved Ratio Impaired Spirometry ('PRISm') and 32% to airflow limitation ('low-limited'); besides, 3.8% participants with normal FEV₁ showed airflow-limitation ('normal-limited'). Low-lim

SUBMITTER: Olvera N 

PROVIDER: S-EPMC11964992 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature