Characterization of the effect of naltrexone/bupropion on body composition.

ABSTRACT:

Aims

Oral treatment extended-release naltrexone/bupropion (NB) leads to significant weight loss, but its effect on body composition remains unclear. We investigated changes in body composition with dual-energy x-ray absorptiometry after treatment with NB or placebo in a subgroup of participants from a randomized control phase 3 study (COR-I).

Materials and methods

Observed changes from baseline to week 52 were estimated for total, lean, and fat mass. Changes in body composition were evaluated using linear regression and adjusted for baseline covariates.

Results

The analysis included 82 participants (placebo, n = 26; NB, n = 56) with comparable baseline characteristics (age, BMI, sex). The NB group experienced a significant -7.8% change of total mass (-12.9% change in

SUBMITTER: Tardio V 

PROVIDER: S-EPMC11965020 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature