A systematic literature review on the burden of diabetic ketoacidosis in type 2 diabetes mellitus.

ABSTRACT:

Aim

To understand the existing literature on the epidemiology and clinical, humanistic, and economic burden of diabetic ketoacidosis (DKA) in people living with type 2 diabetes mellitus (T2DM).

Materials and methods

MEDLINE, Embase and the Cochrane library were systematically searched for studies published between 1 January 2014 and 14 December 2023. Clinical trials and observational studies, conducted in people living with T2DM, were included if they provided data on DKA epidemiology, morbidity, mortality, hospitalizations or patient-reported outcomes. Studies of DKA-associated costs in T2DM were also included. Data were summarized descriptively.

Results

Overall, 197 publications were included. We found wide variations in DKA prevalence (0.0%-50.0%; 5th-95th percenti

SUBMITTER: Wysham C 

PROVIDER: S-EPMC11965021 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature