The role of preeclampsia in breast cancer risk: insights from Mendelian randomization study.

ABSTRACT:

Background

The relationship between preeclampsia and breast cancer risk is still debated, with observational studies yielding inconsistent results. This research aims to clarify the causal link between preeclampsia and breast cancer using Mendelian randomization (MR) methods.

Methods

We utilized genome-wide association study (GWAS) data to identify single nucleotide polymorphisms (SNPs) that are significantly associated with preeclampsia, which served as genetic instruments. A two-sample Mendelian randomization (TSMR) approach was applied, primarily using inverse variance weighting (IVW) to assess the causal impact of preeclampsia on breast cancer risk. To strengthen our findings, a meta-analysis of IVW estimates from both discovery and validation cohorts was performed, comp

SUBMITTER: Qian C 

PROVIDER: S-EPMC11965039 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature